Fig. 18 Left eye of a 78-year-old woman with Best's vitelliform macular dystrophy, showing central choroidal atrophy with loss of retinal pigment epithelium and choriocapillaris, similar to what has been called central choroidal sclerosis. The visual acuity was 20/400. This woman is individual II-2 in the pedigree reported by Stone et al.118 that demonstrated linkage of Best's disease with markers on chromosome 11q13. (From Stone EM: Heritable disorders of RPE, Bruch's membrane, and the choriocapillaris. In Wright K, Ellis F, Mets M, et al [eds]: Pediatric Ophthalmology. Philadelphia: JB Lippincott, 1995)