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Flow cytometric analysis of the Th1-Th2 balance in the development of anterior chamber-associated immune deviation |
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| Flow cytometric analysis of the Th1-Th2 balance in the development of anterior chamber-associated immune deviation |
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作者：Shuxing … 文章来源：第三军医大学大坪医院野战外科研究所眼科, 重庆 400042) 点击数：3079 更新时间：2007/6/20 10:56:34 
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| Abstract
Intracameral injection of soluble protein antigens may elicit a deviant immune response, known as anterior chamber-associated immune deviation (ACAID), ACAID has been shown to be essential in the protection against sight-threatening immune responses . However, the exact mechanisms of ACAID are still not fully understood. Here, we investigated the role of CD4+CD25+ regulatory T (Treg) cells in the development of ACAID. An increased frequency of CD4+CD25+ T cells and up-regulation of the mRNA for Foxp3 was observed. The CD4+CD25+ T cells from mice with ACAID showed enhanced suppression effect on the proliferation of CD4+CD25－ T cells. Treatment of BALB/c mice with anti-CD25 antibody after injection of OVA into the anterior chamber significantly inhibited the induction of ACAID. Furthermore, purified CD4+CD25+ T cells from the mice with ACAID secreted IL-10, but not TGF-beta1. Taken together, our results demonstrate that CD4+CD25+ regulatory T cells are induced in the mice undergoing ACAID. These Treg cells may play an important role in the development of ACAID.
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