|
|
 |
专题栏目 |
 |
|
相关文章 |
|
|
|
|
|
 |
Pharmacokinetics of Chlorhexidine gluconate 0.02% in the rabbit cornea |
热 |
|
| Pharmacokinetics of Chlorhexidine gluconate 0.02% in the rabbit cornea |
|
作者：Sun Xugu… 文章来源：Department Ocular Microbiology, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, China，100005 点击数： 更新时间：2006-6-5 19:58:04 
|
|
| Purpose: To determine the pharmacokinetic parameters of chlorhexidine gluconate in the rabbit cornea. Methods: Each eye of 16 New Zealand white rabbits were topically instilled with 50mL of chlorhexidine gluconate 0.02% eye drop twice with a 5-minute interval. Four corneas of two rabbits were harvested at each time point. The concentration of chlorhexidine gluconate in the cornea was determined with high performance liquid chromatography (HPLC) and 3P87 software to simulate the pharmacokinetic parameters. Results: The concentration of chlorhexidine gluconate in the cornea displayed open two-compartment model. Tmax was 13.75 minutes, Cmax 0.713 ug×g-1 , clearance rate 1.64 ug× g-1× min-1 , and t1/2a, t1/2b, t1/2ka was 2.65 minutes, 48.72 minutes, 2.67 minutes, respectively. Conclusion: The concentration of chlorhexidine gluconate in the rabbit cornea could be determined by means of HPLC. The maximum concentration of chlorhexidine gluconate in the corneal tissue was much higher than the trophozoite minimum amoebicidal concentration (TMAC) in vitro.
|
|
|
| 会议投稿录入：justliang 责任编辑：毛进 |
|
|
上一篇会议投稿： 5-氟尿嘧啶联合曲安奈德治疗眼睑海绵状血管瘤的临床观察
下一篇会议投稿： 应用滴眼剂导致急性鼻炎分析 |
|
|
| 【字体：小 大】【发表评论】【加入收藏】【告诉好友】【打印此文】【关闭窗口】 |
|
 网友评论：（只显示最新10条。评论内容只代表网友观点，与本站立场无关！） |
| |
|
|
|
|
