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src='/guanggao12/200605/9.js'></script></td></tr> </table> </td> <td width="5"></td> <td width="1" bgcolor="#EEEEEE"></td> <td width="5"></td> <td valign="top"> <table width="100%" border="0" cellpadding="0" cellspacing="0"> <tr><td> <table width="100%" align="center" border="0" cellpadding="0" cellspacing="0"> <tr><script language='javascript' src='/guanggao12/200605/6.js'></script></tr> </table> <table width="100%" align="center" border="0" cellpadding="0" cellspacing="0"> <tr><td height="22"><img src="/Skin/sealove/icon02.gif"></td> <td>Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in pigment epithelium cells in vitro</td> <td align="right">&nbsp;&nbsp;&nbsp;<font color=red>p</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<font color='#009999'></font></td> </tr> </table> <table width="100%" align="center" border="0" cellpadding="0" cellspacing="0"> <tr><td height="1" bgcolor="#EEEEEE"></td></tr> <tr><td height="35" align="center" class="main_ArticleTitle" style="word-break:break-all;Width:fixed">Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in pigment epithelium cells in vitro</td></tr> <tr><td class="main_ArticleSubheading" style="word-break:break-all;Width:fixed"></td></tr> <tr><td height="23" align="center" class="Article_tdbgall">\O<a href='/ShowAuthor.asp?ChannelID=8&AuthorName=Wen-ChuanWu a, Ying-Hsien Kao b,' title='Wen-ChuanWu a, Ying-Hsien Kao b,'>Wen-Chua& </a> ezegn<a href='/ShowCopyFrom.asp?ChannelID=8&SourceName=Departments of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan'>Departments of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan</a> pQpe<script language='javascript' src='/meeting/GetHits.asp?ArticleID=17775'></script> fee2008-5-21 9:49:27 <a href="javascript:d=document;t=d.selection?(d.selection.type!='None'?d.selection.createRange().text:''):(d.getSelection?d.getSelection():'');void(vivi=window.open('http://vivi.sina.com.cn/collect/icollect.php?pid=2008&title='+escape(d.title)+'&url='+escape(d.location.href)+'&desc='+escape(t),'vivi','scrollbars=no,width=480,height=480,left=75,top=20,status=no,resizable=yes'));vivi.focus();" title="6eυvQu\8lEN0WOX[0RejmViVi6eυ9Yhttp://vivi.sina.com.cn"><img src="/images/vivi_coop1.gif" border="0" align="absmiddle"></a> <script type="text/javascript" charset="utf-8"> (function(){ var _w = 72 , _h = 16; var param = { url:location.href, type:'3', count:'1', /**/f&T>f:yRNpe 1>f:y(S )*/ appkey:'http://www.oculist.net', /**`3uv^(uappkey,>f:yRNegn(S )*/ title:'', /**RNveW[Q[(S ؞:N@b(Wubvtitle)*/ pic:'', /**RNVGrv_(S )*/ ralateUid:'1943293590', /**sQT(u7bvUID RN_ZSO@(u7b(S )*/ rnd:new Date().valueOf() } var temp = []; for( var p in param ){ temp.push(p + '=' + encodeURIComponent( param[p] || '' ) ) } document.write('<iframe allowTransparency="true" frameborder="0" scrolling="no" src="http://hits.sinajs.cn/A1/weiboshare.html?' + temp.join('&') + '" width="'+ _w+'" height="'+_h+'"></iframe>') })() </script> </td></tr> <tr><td height="6"></td></tr> <tr><td id="fontzoom"><script language='javascript' src='/guanggao12/200605/7.js'></script>Abstract Hypoxia is the most common factor contributing to the pathogenesis of choroidal neovascularization, which is the major cause for blindness and occurs in proliferative diabetic retinopathy and age-related macular degeneration. The purpose of this study is to investigate the role of retinal pigment epithelial (RPE) cells in the regulation of subretinal neovascularization under hypoxia and the possible function of a heat shock protein 90 (HSP90) inhibitor, geldanamycin (GA), in the regulation of VEGF expression. An in vitro hypoxic experimental model was used to mimic the ischemic microenvironment of RPE cells. The cell growth was measured by proliferation assay and the morphological observation was documented by microscope. The gene expression of VEGF, HSP70, HSP90aand HSP90b were measured using semi-quantitative RT-PCR. The VEGF release from RPE cells were detected by ELISA. No alteration in growth rate and cell morphology under 1% O2 condition for 24h was noticed. The proangiogenic growth factor VEGF, but not bFGF, released from hypoxia-treated cells were higher than that of normoxic control. A similar tendency of VEGF gene expression, detected by RT-PCR, was noticed in hypoxia-treated cells. Heat shock pretreatment elevated HSP70 and VEGF gene expression and augmented the hypoxia-induced VEGF gene expression and protein release. Pretreatment with GA can significantly suppress the hypoxia-induced VEGF gene expression in and peptide release from RPE cells. This in vitro finding suggests that HSP90 inhibitors could be considered as a novel anti-angiogenesis agent for diseases with intraocular neovascularization. <center></center></td></tr> <tr><td><script type="text/javascript" charset="utf-8"> (function(){ var _w = 142 , _h = 66; var param = { url:location.href, type:'4', count:'1', /**/f&T>f:yRNpe 1>f:y(S )*/ appkey:'http://www.oculist.net', /**`3uv^(uappkey,>f:yRNegn(S )*/ title:'', /**RNveW[Q[(S ؞:N@b(Wubvtitle)*/ pic:'', /**RNVGrv_(S )*/ ralateUid:'1943293590', /**sQT(u7bvUID RN_ZSO@(u7b(S )*/ rnd:new Date().valueOf() } var temp = []; for( var p in param ){ temp.push(p + '=' + encodeURIComponent( param[p] || '' ) ) } document.write('<iframe allowTransparency="true" frameborder="0" scrolling="no" src="http://hits.sinajs.cn/A1/weiboshare.html?' + temp.join('&') + '" width="'+ _w+'" height="'+_h+'"></iframe>') })() </script></td></tr> <tr><td><script language='javascript' src='/guanggao12/200605/7.js'></script></td></tr> <tr><td align='right' class="Article_tdbgall">Ob?zU_eQkۏ&nbsp;&nbsp;&nbsp;&nbsp;#Nkۏ&nbsp;</td></tr> <tr><td height="1" background="/Skin/sealove/line01.gif"></td></tr> <tr><td height="6"></td></tr> <tr><td><li> NN{Ob?z l gN</li><br><li> NN{Ob?z <a class='LinkNextArticle' href='/meeting/HTML/17776.html' title='ezhؚSm^a|TؚSm^\ }[SOYW{QvƉQ Mller~ހހQ[Ca2+]ivq_T \O&nbsp;&nbsp;&nbsp;&nbsp;[ Ng ~V c[ sQ\^ kf fee2008-5-21 9:46:49'>ؚSm^a|TؚSm^\ }[SOYW{QvƉQ Mller~ހހQ[Ca2+]ivq_T</a></li></td></tr> <tr><td height="6"></td></tr> <tr><td height="1" bgcolor="#CCCCCC"></td></tr> <tr><td height="22" bgcolor="#F2F2F2" align="right">0W[SO<a href="javascript:fontZoomA();" class="top_UserLogin">\</a> <a href="javascript:fontZoomB();" class="top_UserLogin">'Y</a>00<a href="/meeting/Comment.asp?ArticleID=17775" target="_blank">Shċ</a>00<a href="/User/User_Favorite.asp?Action=Add&ChannelID=8&InfoID=17775" target="_blank">ReQ6eυ</a>00<a href="/meeting/SendMail.asp?ArticleID=17775" target="_blank">JTɋ}YS</a>00<a href="/meeting/Print.asp?ArticleID=17775" target="_blank">SbpSdke</a>00<a href="javascript:window.close();">sQ핗zS</a>0 </td></tr> <tr><td height="1" bgcolor="#CCCCCC"></td></tr> </table> <table width="100%" align="center" border="0" cellpadding="0" cellspacing="0"> <tr><td height="25">0<img src="/Images/TEAM.gif" align="absmiddle">0<b>QSċ</b>S>f:yge10ag0ċQ[SNhQS‰p N,gzz:WesQ </td></tr> <tr><td class="main_tdbg_760"> <script language='javascript' src='/meeting/Comment.asp?Action=JS&CommentNum=10&ArticleID=17775'></script> </td></tr> </table><br> </td> </tr> </table> </td> <td width="5"></td> <td width="8" background="/Skin/sealove/Main_Right.gif"></td> </tr> </table> <table width="1000" align="center" border="0" cellpadding="0" cellspacing="0" bgcolor="#FFFFFF"> <tr><td width="8" background="/Skin/sealove/Main_Left.gif"></td> <td valign="top"> <table width="100%" border="0" cellpadding="0" cellspacing="0"> <tr><td height="1" bgcolor="#0099BB"></td></tr> <tr><td height="1"></td></tr> <tr><td height="9" bgcolor="#0099BB"></td> </tr> <tr><td height="1"> <script src="http://www.google-analytics.com/urchin.js" type="text/javascript"> </script> <script type="text/javascript"> _uacct = "UA-358443-1"; 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