TABLE 5. Prophylaxis of Cystoid Macular Edema with Topical Nonsteroidal Anti-Inflammatory Drug Treatment: Double-Masked, Randomized, Placebo-Controlled Studies


Authors Dose regimen Examination time Angiographic CME† Improved vision† NSAID
Miyake et al239 (1980)* 1 gtt t.i.d. for 2 wk after surgery 1–2 mo
4–7 mo
12–18 mo
Decreased
Decreased
Same
Yes
No
No
1% Indomethacin in sesame seed oil
Yannuzzi243 (1981)* 1 qt q.i.d. for 4–6 wk after surgery 5 wk
10 wk
52 wk
Decreased
Same
Same
No
No
No
1% Indomethacin suspension
Kraff, Sanders, Jampol et al235 (1982)* 1 gtt q.i.d. for 9 mo after surgery 2–12 mo Decreased No 1% Indomethacin suspension
Flach, Stegman, Graham96 (1990) 1 gtt t.i.d. for 19 days after surgery 1 mo Decreased No 0.5% Ketorolac solution
Solomon, et al246
Flurbiprofen-CME Study Group I (1995)*
1 gtt q.i.d. 2 days before surgery and for 3 mo after surgery 21–60 days and 120–240 days Decreased Yes (Contrast sensitivity)
No (Snellen)
0.03% Flurbiprofen
1% Indomethacin suspension


*Studies included steroids concurrently.
†NSAID treatment vs. placebo treatment.
CME, cystoid macular edema; NSAID, nonsteroidal anti-inflammatory drugs.