TABLE 2. Nonsterioidal Anti-Inflammatory Drugs and Inhibition of Intraoperative Miosis

Investigator (no. of patients) year	NSAID	Dose regimen	Coexisting treatment	Change in pupil diameter (mm)
Investigator (no. of patients) year	NSAID	Dose regimen	Coexisting treatment	Drug (no. of patients)	Vehicle (no. of patients)	Statistical significance*
Keulen-DeVos¹⁵⁴ (64) 1983	Indomethacin 0.5% solution	1 gtt 7:00 PM and 9:00 PM night before surgery and 2, 1, and 1/4 hr before surgery	0.5% tropicamide, 5% phenylephrine	−2.44 (32)	−3.12 (32)	p = 0.01
Keates¹⁵³ (106) 1984	Indomethacin 1% suspension	1 gtt 5:00 PM and 9:00 PM night before surgery and 1 gtt 1, ¾, and ½ hr before surgery	1% tropicamide, 2.5% phenylephrine	−0.27 (55)	−0.84 (51)	p = 0.001
Keates¹⁴⁹ (34) 1984	Flurbiprofen 0.03% solution	1 gtt at 6:00 AM and 7:00 AM and 1, ¾, and ½ hr before surgery	1% tropicamide, 2.5% phenylephrine	−2.5 (16)	−3.9 (18)	p = 0.003
Stark¹⁵⁰ (412) 1986	Suprofen 1% solution	2 gtt every 4 hr the day before surgery, and 2 gtt every hr × 3 before surgery	Variable and including intraoperative epinephrine in some cases	−1.01 (209)	−1.48 (203)	p = 0.001

* All results favor nonsteroidal anti-inflammatory drug (NSAID) treatment over placebo.