Fig. 14. Trisomy 21. A and B. Brushfield spots in the iris of the right and left eyes of a 33-year-old woman with Down syndrome (A, SEI 79-30; B, SEI 79-31). C. Brushfield spot seen as an area of relatively normal, or mildly hypercellular, iris stroma (between arrows) surrounded by a hypoplastic iris (PAS, × 101 [SEI 73–274]).