Fig. 22 A. Clinical photograph of a patient with chronic central serous chorioretinopathy (CCSC). Note the areas of retinal pigment epithelial atrophy, especially superiorly. There is a large neurosensory retinal detachment with white fibrin along the inferior arcade. B. Late-phase ICG study demonstrating the choroidal hyperpermeability and staining of fibrin. This area was treated in a pilot study using ICG-guided photodynamic therapy with verteporfin. C. ICG study 3 weeks after treatment reveals the characteristic circular hypofluorescence found after PDT treatment. There is a decrease in the choroidal hyperpermeability.