Fig. 20. Effect of intracameral exchange (Ex) infusion with 10 to 500 μM H-7 on outflow facility in monkeys. BL, baseline; Res, reservoir. Data are mean ± standard error of the mean (SEM) μL/min/mm Hg for n animals, each contributing one H-7– and one vehicle-treated eye. Percentages show the increases of overall facility in H-7–treated eyes within 45 minutes post-drug perfusion, compared to contralateral vehicle-treated eyes and corrected for corresponding baselines (in B, item (a) represents the increase for the first 30 minutes, item (b) represents the increase for the second 30 minutes). *p < 0.05, **p < 0.005, ***p < 0.001 for ratios different from 1.0 by the two-tailed paired t test. (From Kaufman PL, Tian B, Gabelt BT, et al: Outflow enhancing drugs and gene therapy in glaucoma. In Weinreb R, Krieglstein G, Kitazawa Y, eds.: Glaucoma in the 21st Century. London: Harcourt-Mosby, 2000:117–128, with permission.)