Fig. 29. Amniotic band syndrome producing craniofacial defects, including large cranial encephalocoele, nasal clefts, and medial orbital clefts with severe upper lid deformities, and globe exposure. (Fries PD, Katowitz JA: Congenital craniofacial anomalies of ophthalmic importance. Surv Ophthalmol 35:87, 1990, with permission from Elsevier Science.)