Fig. 18 Congenital corneal leukoma. A. Central, elevated, dense, vascularized opacity occupies the central cornea. B. Central posterior corneal defect (long arrow) creates shallow stromal depression with overlying scarring and vascularization (PAS, ×4). Right inset. Descemet's membrane terminates at the edge of the posterior corneal defect (short arrows) (PAS, ×256). Left inset. Drawing emphasizes the lack of iris and lens abnormalities. (Waring GO, Rodrigues MM, Laibson PR: Anterior chamber cleavage syndrome. Surv Ophthalmol 20:3–27, 1975)