Fig. 6. A. Fundus photograph and B. fluorescein angiogram demonstrating diffuse vaso-occlusive disease in a patient with systemic lupus erythematosus. This is peripheral nonperfusion of the retina. The patient had anticardiolipin antibodies. (Jabs DA, Fine SL, Hochberg MC, et al: Severe retinal vaso-occlusive disease in systemic lupus erythematosus. Arch Ophthalmol 104:558, 1986. Copyrighted 1986, American Medical Association. Reprinted with permission.)