Fig. 5. Birefringence of ganglion cell layer of macula in Tay-Sachs disease. Frozen section, cresyl violet stain, photographed between crossed polaroids (x 80). (Cogan DG, Kuwabara T: The sphingolipidoses and the eye. Arch Ophthalmol 79:437, 1968. Copyright © 1968, American Medical Association)