Fig. 6. Arteriolar sclerosis develops in prolonged hypertension and is manifest by increased light reflex, arteriovenous nicking copper or silver wire arterioles. A. Grade I hypertension and grade I arteriolar sclerosis showing the earliest generalized narrowing with increase light reflex. B. Grade I hypertension showing generalized narrowing and grade II arteriolar sclerosis showing increase in light reflex plus arteriovenous compression. C. Grade I hypertension showing generalized narrowing and grade III arteriolar sclerosis showing broad light reflex, arteriovenous compression plus copper wire arterioles. D. Grade I hypertension plus grade IV arteriolar sclerosis showing increase of light reflex, arteriovenous compression, copper and silver wire arterioles. (Scheie HG, Ashley BJ, Yanoff M: Medical ophthalmology: Hypertension and arteriosclerosis. In Scheie HG [ed]: Medical Ophthalmology: Ophthalmologic Manifestations of Systemic Diseases, p 17. Elgin, IL: Medicolor Illustration and Editorial Service, 1966)