Fig. 2 A. A 65-year-old man with a myelodysplastic disorder and pancytopenia developed a pimple on the side of his nose followed by rapidly developing cellulitis and skin necrosis. The patient developed a frozen globe and loss of vision over a matter hours. Despite aggressive surgical debridement of the necrotic areas and intravenous, amphotericin, the patient died. B. Black eschar (necrosis) along right side of nose, ala, upper lip, and hard palate. C. Right orbital infiltration is seen along with opacification of the right ethmoid sinus and nasal passage. D. The optic nerve is on stretch with tethering of the globe, extensive soft tissue swelling anteriorly, ethmoidal opacification, and enlargement of the right medial rectus muscle.