Fig. 4. A hypothetical scheme of the major structures that project to the brainstem saccade generator (premotor burst neurons in PPRF and riMLF). Also shown are projections from cortical eye fields to superior colliculus. FEF, frontal eye fields; SEF,-supplementary eye fields; DLPC, dorsolateral prefrontal cortex; IML, intramedullary lamina of thalamus; PEF, parietal eye fields (LIP); PPC, posterior parietal cortex; SNpr, substantia nigra, pars reticulata. Not shown are the pulvinar, which has connections with the superior colliculus and both the frontal and parietal lobes, and certain projections, such as that from the superior colliculus to nucleus reticularis tegmenti pontis (NRTP). B: Probable location of cortical areas important for eye movements in human brain. FEF, frontal eye field; LIP, lateral intraparietal area; MST, medial superior temporal visual area; MT, middle temporal visual area (V5); SEF, supplementary eye field; SMA, supplementary motor area; V1, primary visual cortex. (Adapted from Leigh RJ, Zee DS: The Neurology of Eye Movements, 3rd ed. Oxford University Press, New York, 1999.)